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Patent Number: 9,051,354

Protein charge regulator and protein-encapsulating polymer micelle complex

Abstract The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention comprises a cationic polymer having a polycation moiety and a charge-conversional protein whose overall charge is converted from basic or neutral to acidic by a specific charge regulator.
Filing Date: September 17, 2009 Issue Date: June 9, 2015 Link: USPTO website

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