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Patent Number: 9,051,387

Inhibition of MyBP-C binding to myosin as a treatment for heart failure

Abstract The present invention provides for methods of treating and slowing the onset of heart failure. The inventors have determined that myosin binding to unphosphorylated Myosin Binding Protein C (MyBP-C) plays a key role in the diminution of cardiac contractile force and frequency in heart failure. The present invention provides peptide inhibitors of the MyBP-C/myosin interaction, thereby increasing both cardiac contractile force and frequency in the failing heart, as well as in patients not yet exhibiting frank heart failure.
Filing Date: March 14, 2013 Issue Date: June 9, 2015 Link: USPTO website

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