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Patent Number: 9,051,551

Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors

Abstract The present invention relates to a method for sensitizing a disease cell expressing the epidermal growth factor receptor (EGFR) to a tyrosine kinase inhibitor selective or specific for EGFR and/or its signalling pathway, the method comprising contacting the cell with a miR-7 miRNA, a precursor or variant thereof, or a miRNA comprising a seed region comprising the sequence GGAAGA.
Filing Date: November 24, 2010 Issue Date: June 9, 2015 Link: USPTO website

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